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Anti-angiogenesis Chemotherapy Agents: the Role of Anti-angiogenesis at Cancer Treatment
Duygu Citak
Anti-angiogenesis Chemotherapy Agents: the Role of Anti-angiogenesis at Cancer Treatment
Duygu Citak
Angiogenesis can be explained as the growth of new blood vessels from pre-existing vasculature. It has an important and vital role in growth and development, as well as in wound healing. Anti-angiogenic substances suppress the growth of new blood vessels so prevent nutrients and oxygen needed for the growing of tumor cells. It is proposed that tumor angiogenesis could serve as a potential target for anticancer therapy. Combretastatin (CA-4) is an anti-angiogenesis agent that inhibits the tubulin polymerization. CA-4 exhibits anti-tumor effects through the well-organized therapeutic mechanism of tumor blood supply disabling. By affecting selectively and blocking tumor vasculature, CA-4 reduces the blood supply needed for tumor growth and survival. As a result of oxygen poverty and build-up of tumor metabolic by-products causes the death of the cancer cells within the central core of the tumor. In this thesis, covalent modification of CA-4 has been investigated. Variety of CA-4 analogs which involved blocking the free alcohol group has been synthesized.
Media | Boeken Paperback Book (Boek met zachte kaft en gelijmde rug) |
Vrijgegeven | 1 september 2011 |
ISBN13 | 9783845420097 |
Uitgevers | LAP LAMBERT Academic Publishing |
Pagina's | 80 |
Afmetingen | 150 × 5 × 226 mm · 127 g |
Taal en grammatica | Engels |
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