Michel Leclerc

Adaptative Immunity in Echinodermata Michel Leclerc

In the years 1980, We have discovered vaccination in Echinodermata by immunizations with various antigens (with or without Freund'adjuvant).
Later, with co-workers, I discovered the sea star IgKappa gene. Its sequence was composed of about 435 nucleotides.
We have studied the effects of sea star IgKappa gene on cancerous human cells (Hela cells, Melanoma cells). Mainly the sea star Igkappa gene, incorporated in a plasmid (CMV plasmid), exerts a high spontaneous cytotoxicity against Hela cells.
But it doesn't constitute, in fact, in the present time, a good therapy for Cancer diseases.
On the other hand, we consider that the sea star Igkappa gene and the IPA (Invertebrate primitive antibody) are "PRIMITIVE".
So, as "Young" elements, they may play a role, in immunotherapy of various diseases. It is why, we envisage to use them in coronavirus disease and particularly Covid 19 disease. We think that this primitive antibody may add a positive effect to immunodeficience pathology which was provoked by covid invading. As young researcher, I look for co-workers who can help me in this work.